Who makes Kirkland Signature Esomeprazole Magnesium (20 mg), 42 Delayed-Release Capsules?
As of August 30, 2026, the manufacturer of Kirkland Signature Esomeprazole Magnesium (20 mg), 42 Delayed-Release Capsules is Perrigo, per plant / registration code evidence.
The common claim
What most answers say — and what the evidence supports
Store-brand roundups and heartburn forums generally credit Perrigo - the largest US maker of private-label OTC drugs - and both FDA drug records and Costco's own listing line up with that. Costco markets the Kirkland Signature Esomeprazole Magnesium 20 mg delayed-release capsules (NDC 63981-898) under ANDA 207193, whose Drugs@FDA applicant is Perrigo (PERRIGO R AND D); the same application also covers Perrigo's own version of this product, Good Sense Esomeprazole Magnesium. Costco's own product listing for the 42-count carton independently carries "L Perrigo Company" in its manufacturer field. The two routes agree: Kirkland Signature esomeprazole is manufactured by Perrigo, per Costco's product-catalog manufacturer field (L. Perrigo Company) corroborated by FDA's Drugs@FDA record for ANDA 207193. The FDA route alone is indirect - openFDA's NDC manufacturer_name names only the Costco labeler, the maker is reached through the NDC-to-ANDA-to-sponsor join, and an ANDA holder is FDA's responsible party rather than a guaranteed physical packer - which is why the retailer's own field naming the same company is what closes the attribution.
Evidence & sources
Every source is graded on the six-tier rubric and archived, so the citation holds even if the original moves or paywalls. The tier badge grades the source; the status grades our confidence in the maker.
Tier 3
DailyMed's FDA-sourced label "KIRKLAND SIGNATURE ESOMEPRAZOLE MAGNESIUM (ESOMEPRAZOLE) CAPSULE, DELAYED RELEASE" (SPL published 2024-08-09) names Costco Wholesale Company as the labeler (establishment DUNS 103391843), lists NDC 63981-898 (esomeprazole magnesium 20 mg delayed-release capsules; a 3-bottle, 42-capsule carton marketed since 2017-09-22), and gives Marketing Category "Abbreviated New Drug Application" with Application Number ANDA207193. No establishment or registrant other than Costco appears on the SPL, so the deterministic link runs through the ANDA number rather than an on-label maker line. This is the brand-to-ANDA anchor; the sibling Drugs@FDA record resolves ANDA207193 to Perrigo.
Tier 3
FDA's Drugs@FDA database resolves ANDA207193 - the application under which Costco markets the Kirkland Signature Esomeprazole Magnesium 20 mg delayed-release capsules (NDC 63981-898) - to sponsor/applicant PERRIGO R AND D, product ESOMEPRAZOLE MAGNESIUM (EQ 20MG BASE), delayed-release capsule, over-the-counter. The same record shows L. Perrigo Company marketing its own version of this exact product - Good Sense Esomeprazole Magnesium (Perrigo labeler code 0113; NDC 0113-0898, 0113-0651, 0113-2022) - under the identical ANDA, direct corroboration that Perrigo is the application holder for the product Costco relabels as Kirkland. Perrigo is the largest US maker of private-label OTC drugs. On its own this join would cap the grade at probable: openFDA's NDC manufacturer_name only echoes the labeler (Costco), so the maker is reached via the two-table NDC->ANDA->sponsor join; the ANDA applicant is FDA's responsible party but is not guaranteed to be the physical packer, and store-brand OTC lines are commonly multi-sourced. Costco's own catalog manufacturer field naming L. Perrigo Company for the same item (see the Costco Business Delivery source) is the independent corroboration that carries the record to confirmed (DECISIONS 2026-08-30). Independent corroboration that Perrigo sits in Costco's OTC supply chain: FDA recall D-0355-2022 (Class II, 2021) describes "KIRKLAND ALLER-FEX, Fexofenadine Hydrochloride Tablets, 180 mg... Packaged by Perrigo 515 Eastern Ave., Allegan, MI 49010, For Costco Wholesale Corporation" - a sibling antihistamine, not esomeprazole itself.
Tier 4
Costco's Business Delivery storefront (costcobusinessdelivery.com) serves the same US catalog data as costco.com and, unlike costco.com, can be fetched and archived. Its page for this item - 'Kirkland Signature Esomeprazole Magnesium Acid Reducer, 20 mg Delayed-Release Capsules, 42 ct' (item 100299212) - embeds catalog JSON whose manufacturer field reads mfName: "L PERRIGO COMPANY", L. Perrigo Company being Perrigo's principal US operating company (Allegan, MI). Read on August 30, 2026 and verified present in the Wayback snapshot created the same day. The costco.com consumer page for the same product (item 100382995) was also read live in a browser that day and carries the identical mfName value; costco.com cannot be archived, so the Business Delivery page is the citable copy. An internal catalog field rather than an editorial statement, and such fields can name a supplier-of-record rather than the plant; here it independently corroborates the FDA route (NDC 63981-898 -> ANDA 207193 -> sponsor Perrigo R&D) - the retailer and the regulator naming the same company - which satisfies the mfName-plus-independent-naming rule for confirmed (DECISIONS 2026-08-30). The ANDA holder remains FDA's responsible party rather than a guaranteed physical packer; the retailer's own field agreeing with it is what closes the attribution.
Frequently asked
Who makes Kirkland Signature esomeprazole for Costco?
Is Kirkland esomeprazole the same as Nexium?
Has Kirkland esomeprazole ever been recalled?
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